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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
The Effects of Gut Microbiome Manipulation on Glycemic Indices in Patients with Non-Alcoholic Fatty Liver Disease: A Comprehensive Umbrella Review
[Nutrition & Diabetes] A systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library until March 2023 for meta-analyses evaluating the effects of probiotics, prebiotics, and synbiotics on patients with NAFLD.
TREM2 Protects Against Inflammation by Regulating the Release of Mito-DAMPs From Hepatocytes During Liver Fibrosis
[Free Radical Biology And Medicine] Scientists demonstrated that TREM2 was upregulated in murine model with liver fibrosis. Mice lacking TREM2 exhibited reduced phagocytosis activity in macrophages following carbon tetrachloride intoxication.
‘Remarkable Interest’: Madrigal Touts Early Launch Progress for First MASH Drug Rezdiffra Despite VA Hurdle
[Fierce Biotech] With $1.1 billion cash on Madrigal Pharmaceuticals’ balance sheet, CEO Bill Sibold believes the company can “fully resource” the launch of Rezdiffra, the first FDA-approved therapy for fatty liver disease.
The Prognostic Significance and Potential Mechanism of DBF4 Zinc Finger in Hepatocellular Carcinoma
[Scientific Reports] The authors evaluated the impact of DBF4 on proliferation, migration, and invasion of HCC cells. RNA sequencing and KEGG pathway enrichment analysis were also conducted to identify potential pathways, which were further validated through WB experiments.
Thy-1 Restricts Steatosis and Liver Fibrosis in Steatotic Liver Disease
[Liver International] The impact of Thy-1 on the development of SLD and progression to fibrosis was investigated in high-fat diet-induced SLD wild-type and Thy-1-deficient mice.
ZNF469 Is a Profibrotic Regulator of Extracellular Matrix in Hepatic Stellate Cells
[Journal Of Cellular Biochemistry] Investigators showed that knockdown of ZNF469 in primary human HSCs impaired proliferation, migration, and collagen production. Conversely, overexpression of ZNF469 in HSCs yielded the opposite results.
Exploiting In Silico Modelling to Enhance Translation of Liver Cell Therapies from Bench to Bedside
[NPJ Regenerative Medicine] The authors highlight three therapies, each utilising a different cell type, at different stages in their clinical translation journey: transplantation of multipotent mesenchymal stromal/signaling cells, hepatocytes, and macrophages.
Winners of the American Liver Foundation 2024 Poster Competition Announced
[American Liver Foundation (PR Newswire)] Winners from the American Liver Foundation's 2024 Liver Health Poster Competition were announced. This competition showcases posters and a brief video created by early career healthcare professionals from across the country on six areas of liver educational focus.
Multifunctional and Stimuli-Responsive Liposomes in Hepatocellular Carcinoma Diagnosis and Therapy
[Translational Oncology] Researchers evaluated the application of liposomes for the HCC therapy. The drugs and genes lack targeting ability into tumor tissues and cells.
Calreticulin Regulates Hepatic Stellate Cell Activation Through Modulating TGF-Beta-Induced Smad Signaling
[Cell Calcium] In a mouse liver injury model, CRT was up-regulated in hepatic stellate cells. In cellular experiments, scientists showed that this activation was through modulating the canonical TGF-β signaling.
Electric Pulse Exposure Reduces AAV8 Dosage Required to Transduce HepG2 Cells
[PLOS One] Scientists conducted 48 experimental observations across eight exposure conditions in standard well plates. The electric pulse exposures involved single 80-ms pulses with 375 V/cm field intensity.
NAC1 Transcriptional Activation of LDHA Induces Hepatitis B Virus Immune Evasion Leading to Cirrhosis and Hepatocellular Carcinoma Development
[Oncogenesis] Investigators identified candidate genes by intersecting differentially expressed genes with co-expression modules. They validated these genes using the TCGA database, conducting survival analysis to pinpoint key genes affecting HBV-HCC prognosis.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
